Cause of Hypospadias
& Why Hypospadias?

The cause of hypospadias is complex, unclear & unknown in most cases. There are nearly three dozen suspected hypospadias causes.

British research indicates consuming 400 μg folic acid supplements the first 90 days of pregnancy reduces incidence of hypospadias 36% but that is useless info for parents of children who already have hypospadias (unless they plan to have more children). And it doesn't explain the cause of hypospadias, it only suggests a slightly effective method of prevention.

Like most investigations, the cause of hypospadias has “primary suspects” and “suspects of interest”. A suspected hypospadias cause may not work alone and may need a gang of “accomplices” — such as high total pesticide exposure.

Investigations into the cause of hypospadias and why it has doubled during the past half century in some countries are challenging because of the complexity and vast amount of legacy pollutants in the environment and the boatloads of new chemicals being dumped into the air, rivers & oceans daily.

It makes sense to suspect the lethal chemical cocktails which bioaccumulate in humans at the top of the food chain are hypospadias causes.

Researchers have strong evidence that certain suspected causes of hypospadias such as DEP & DBP phthalates increase risk three times if a pregnant mother is exposed during early pregnancy. But even tap water and disinfectants may be hypospadias causes. Yes, tap water.

Solutions for infertility such as IVF may also be a cause of hypospadias.

Whichever suspects listed below cause hypospadias and regardless of the type of hypospadias, Dr Rados Djinovic of the Sava Perovic Surgical Team can repair it and that is the only important information families need to know when hypospadias is already a fact in their lives.

Suspected Hypospadias Causes Include:

• genetics?? (Smith Lemli Opitz gene)
• heredity?? (autosomal dominant inheritance, X chromosome)
• phthalates, such as DEP (diethyl phthalate) & DBP (dibutyl phthalate)?? (3-fold increased risk; used in hairsprays & cosmetics; banned in children's products in USA)
• Topamax?? (topiramate anticonvulsant drug with USFDA “Pregnancy Category D” warning — only category “X” is worse)
• drugs during first trimester of pregnancy??
• Diethylstilbestrol?? (DES, synthetic nonsteroidal estrogen)
• insect repellent use during first trimester??
• high total pesticide exposure??
• exposure to Vinclozilin fungicide?? (animal testing of Vinclozilin exposure produced hypospadias reliably and repeatedly …)
• progesterone hormone treatment during pregnancy?? (5 times greater incidence among IVF ART babies)
• trihalomethanes in tap water??
• exposure to DDT?? (Dichlorodiphenyltrichloroethane and other environmentally persistent, hormonally-active synthetic organic pesticides and legacy pollutants that bioaccumulate and are anti-androgens like DDE)
• use of loratadine antihistamine to treat allergies during pregnancy??
• vegetarianism??
• karma??
• exposure to: hazardous waste, heavy metal, solvents, paints or paint removers, printing ink, glue, anesthetics, cytostatics, fumes from plastic, welding, soldering??
• disturbances in hormone production during prenatal development??
• inadequate testes testosterone production??
• abnormal development or enlargement of scrotal swelling & genital tubercle?? (virilization)
• too few androgen receptors??
• too little prenatal 5-alpha reductase?? (androgen converting enzyme)
• insufficient prenatal androgen stimulation for any reason??
• cigarette smoking during pregnancy or significant passive exposure to tobacco smoke?

     

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